THE SCIENCE
4RE is built on three pillars of dermal architecture: Foundation, Structure, and Delivery. Each ingredient is selected for its mechanism of action — not its marketing appeal.
FOUNDATION — LIPID BARRIER
Your skin’s first line of defense. We rebuild it with ceramide-rich oils that mirror your skin’s natural lipid composition.
Shea Butter — Butyrospermum Parkii. Deep barrier repair, rich in vitamins A, E, and F. Restores moisture without occluding pores.
Rice Bran Oil — Oryza Sativa. Contains gamma-oryzanol and ferulic acid. A ceramide-rich emollient with proven antioxidant protection.
Raspberry Seed Oil — Rubus Idaeus. One of the highest plant-source concentrations of omega-3 and omega-6 fatty acids. Natural UV absorption properties.
STRUCTURE — COLLAGEN DEFENSE
Collagen production declines 1% per year after age 25. 4RE deploys four targeted actives to support your skin’s structural integrity.
Trylagen PCB — A biomimetic peptide complex from CLR Berlin. Supports synthesis of Collagen I, III, and IV — the three types responsible for skin firmness, elasticity, and dermal-epidermal junction integrity. Contains Pseudoalteromonas Ferment Extract, Hydrolyzed Wheat Protein, Hydrolyzed Soy Protein, Tripeptide-10 Citrulline, and Tripeptide-1.
Antarticine — Pseudoalteromonas Antarctica Ferment Extract. An extremophile compound isolated from Antarctic marine bacteria. Adapted to survive -5°C environments. Supports skin’s resilience against environmental stress.
Sepilift DPHP — Dipalmitoyl Hydroxyproline from Seppic. A lipopeptide that supports visible firmness and helps reduce the appearance of fine lines.
NMN (Nicotinamide Mononucleotide) — NAD+ precursor. Supports cellular energy production (ATP) at the mitochondrial level. Your cells need energy to maintain and repair. NMN provides the raw material.
DELIVERY — HYDRATION
Active ingredients are worthless if they can’t reach their target depth. Our delivery system ensures multi-layer penetration.
Snow Mushroom Extract — Tremella Fuciformis. Holds 500x its weight in water — significantly more than standard hyaluronic acid. Its smaller molecular size allows deeper penetration into the skin matrix.
Triple Hyaluronic Acid — Three molecular weights working at three depths. High MW forms a moisture film on the surface. Medium MW hydrates the mid-dermis. Low MW penetrates deep for structural hydration support.
CLINICAL DATA
Results from studies on key ingredients at concentrations used in the 4RE formula:
- -29% wrinkle depth reduction in 30 days
- +128% Collagen I synthesis in 15 days
- +81% Collagen IV synthesis
- 2.6x hydration increase vs. baseline